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KMID : 0980720030220010059
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Keimyung Medical Journal
2003 Volume.22 No. 1 p.59 ~ p.67
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Comparison of Clinical and Ultrasonographic Efficacy of Lornoxicam and Acetaminophen in Patients with Knee Osteoarthritis
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Do Ju-Ho
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Abstract
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This study compared the clinical efficacy as well as knee ultrasonographic efficacy between nonsteroidal anti-inflammatory drug (NSAID) and acetaminophen in the treatment of knee osteoarthritis. I administered 12 mg of lornoxicam (plus 150 ㎍ of misoprostol) as NSAID or 1,950 mg of acetaminophen in 45 randomly selected patients with knee osteoarthritis for 6 weeks. The effectiveness of these drugs on osteoarthritis was assessed by Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC score) and knee ultrasonographic parameters (length of capsular distension and amount of joint effusion) before and after 6-week treatment. Seven patients of lornoxicam group and five patients of acetaminophen group were withdrawed and 33 patients finished this study. The clinical symptoms of osteoarthritis assessed by WOMAC score were improved by 6 weeks after treatment with both lornoxicam and acetaminophen, but the lornoxicam group showed better clinical improvement than acetaminophen group significantly (p<0.05). The length of capsular distension and amount of joint effusion decreased after treatment in both groups, but, there were no significant difference between lornoxicam group and acetaminophen group. The findings showed superior efficacy of lornoxicam clinically. However there were no differences in more objective parameters of efficacy (as ultrasonographic findings of knee). Considering the safety and lower price of acetaminophen than NSAIDs, it is recommended acetaminophen as the initial therapy of osteoarthritis again.
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KEYWORD
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Acetaminophen, Nonsteroidal anti-inflammatory drugs, Osteoarthritis, Ultrasonography
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